R230 Focused-ultrasonicator

  • Treatment Power: .5 to 110 W Avg. Incident Power, 1.5 to 450 W PIP
  • Sample Processing Capacity: 8 tubes in parallel
  • NGS Sample Volumes: 5 to 200 µl

The R230 Focused-ultrasonicator is the next generation AFA® powered instrument, and the first of the R-Series. The R230 can be fully integrated on many liquid handler platforms.

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Technical SpecificationDescription
Primary ApplicationsBead mixing/pellet resuspension, Compound screening, DNA shearing, Hit validation, Low mass sample extraction: FFPE, tissue, and whole blood, Mammalian cell lysis, Target ID & validation
Treatment Power.5 to 110 W Avg. Incident Power, 1.5 to 450 W PIP
Part Number500620
Power Requirements100 to 240 VAC 500VA, 50 to 60 Hz
Operating EnvironmentAmbient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30 to 70%
Operating Temperature5 °C to 40 °C
SafetyComplies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory LabelingCE, ETL Mark (for Product Safety), WEEE
SonoLab VersionSonoLab 10
Operating SystemMicrosoft Windows 10
WCSWCS 3.0 included
ChillerWCS 3.0 (Chiller and WCS in one unit- included with system purchase)
Sample Processing Capacity8 tubes in parallel
NGS Sample Volumes5 to 200 µl
Recommended Batch SizeUp to 384 Samples
Covaris Consumables96 AFA-TUBE TPX plate(with RFID), 384 AFA-TUBE TPX plate (with RFID)1536 AFA-TUBE TPX plate(with RFID)-In development
Upgrade PotentialNo
Associated AccessoriesAutomation Accessories

Key Features

  • Powered by Adaptive Focused Acoustics® (AFA®)
  • On-Deck
  • Isothermal
  • Automation compatible with integrated RFID
  • Automated water management
  • Eliminates columns and centrifugation


  • Controlled, non-contact processing
  • Compatible with most liquid handlers
  • Maintains optimal sample integrity
  • Reduced human error
  • User-defined scheduling for system set-up maximizes laboratory efficiency
  • Higher recovery

Quick Guide:

R230 DNA Shearing Protocols


SIMPLE & SMART Sample Prep with the R230


From Tissues to LC-MS-ready Protein Digests: Automated Sample Preparation Enabled by Adaptive Focused Acoustics® (AFA®) Technology


Enabling Efficiency with Acoustic Energy: High-throughput DNA Shearing


Generating 3 kb DNA for Long-read Sequencing


R230 Focused-ultrasonicator Setup & Instruction Manual

Product Inserts and User Manuals

Covaris Automation Platform Solutions for Pre-analytical Sample Preparation


Automated Clinical Rapid Whole Exome Sequencing with the Covaris R230 Focused-ultrasonicator

Covaris Technical Note with Radboudumc DNA fragmentation is a critical step in the preparation of good quality libraries for next-generation sequencing (NGS). Covaris Adaptive Focused...

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High-Throughput, Low Volume gDNA Extraction from Whole Blood Enabled by Covaris Adaptive Focused Acoustics® (AFA®) and AFA-TUBE™ TPX

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Shearing DNA with Confidence: A Robust Method for Generating 3 kb DNA

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