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      • Instrument Comparison Guide
      • Low-throughput Focused-ultrasonicators
        • S220High power, single-tube sample preparation
        • M220The “Scientist Standard” for single tube processing
      • Mid-throughput Focused-ultrasonicators
        • ME220Compact 1 to 8 sample batch processing
        • ML230Parallel sample processing, up to 8 samples
        • E220evolutionHigh power, 1 to 8 sample batch processing
        • E220High Power, 1 to 96 sample batch preparation system
      • High-throughput Focused-ultrasonicators
        • LE220-plusHigh-throughput, 1 to 96 tube capacity
        • LE220R-plusRobotic version of the LE220-plus
        • LE220Rsc
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        • R230On-deck, next generation Focused-ultrasonicator
      • cryoPREP® Extraction Systems
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      • Nucleic Acids Shearing Kits and Buffers truSHEAR, truPOP, DNA verification kits
      • truXTRAC OtherNucleic Acids Shearing Kits and Buffers, cfDNA, DBS, Proteins, MALDI-TOF
      • Protein Extraction Buffers Native, Total Protein & Detergent-free Buffers
    • Consumables – Tubes and Vials
      • AFA-TubeLaser etched polymer vessel for high-throughput workflows
      • microTUBE Small sample volumes, 130µl or less
      • milliTUBE1ml or 2ml sample volume. Good for chromatin shearing
      • Other AFA Tubes
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      • Sample Prep for Mycobacterium
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Instruments

  • Instrument Comparison Guide
  • Low-throughput Focused-ultrasonicators
    • S220
    • M220
  • Mid-throughput Focused-ultrasonicators
    • ME220
    • ML230
    • E220evolution
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    • LE220-plus
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Focused-ultrasonicator Instruments and Cryoextraction Systems

Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples. Focused-ultrasonicators standardize sample prep for a variety of application areas including DNA/RNA shearing for Next-Gen sequencing, FFPE extraction, chromatin shearing, cell lysis, formulations, and more.
cryoPREP Dry Pulverizers are designed to integrate the tissue processing workflow from flash-freezing to extraction with AFA® Focused-ultrasonicators.

Focused-ultrasonicators

Engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples.
  • Low-throughput
  • Mid-throughput
  • High-throughput
  • On-Deck Automation

cryoPREP® Extraction Systems

cryoPREP Dry Pulverizers deliver a calibrated and repeatable mechanical impact to cryofracture flash-frozen samples without direct sample contact.

SonoLab Software Download

SonoLab is our proprietary software used to control Covaris’ Focused-ultrasonicator instruments allowing millisecond timing control of the focused acoustics.

Instrument Financing

We have partnered with Taycor Financial to provide our customers with first class service for instrument financing. This is in an effort to help provide access to the capital your business needs to get a Focused-ultrasonicator in your lab.
LEARN MORE

Resources

Protocols
Protocols for AFA-enabled applications on Focused-ultrasonicator and cryoPREP instruments.
LEARN MORE

Product Inserts & User Manuals
Product Inserts and User Manuals for Focused-ultrasonicator and cryoPREP instruments, reagent kits and consumables.
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Application Notes
Technical notes, application notes and case studies for AFA-enabled applications.
LEARN MORE

FAQs

What are the DNA fragment sizes I can get using Covaris Focused-ultrasonicator Instruments?

Covaris instruments can provide tunable DNA fragment sizes from 150 bp to 5 kbp. Random shearing with Adaptive Focused Acoustics (AFA) energy generates a log normal distributed DNA fragment profile. We provide protocols for the most commonly required DNA sizes. Click here to learn more about our DNA Shearing protocols. Typically, sizes between the defined protocols may be achieved by increasing the time of the treatment of the nearest size DNA fragment (upper side).

Why do I need to change the water in the tank of my Focused-ultrasonicator everyday?

Purity of the water in the bath is very important for the proper acoustic coupling. When applying acoustic energy in rate-limited applications, foreign material such as algae and particulates may scatter the high frequency focused acoustic beam, resulting in a shift to a larger mean fragment size. Bath water should be deionized water, changed daily unless continuously treated by the optional Covaris Water Conditioning System (available for S, E, and LE instruments). Click to learn more about the WCS System.

Once the sample is pulverized with a cryoPREP Dry Pulverizer, is it mandatory for the sample to be processed immediately, or can it be stored?

No, the pulverized sample does not need to go through any sample processing immediately. After cryofracturing with the cryoPREP, tissueTUBE plugs can be used to seal the tissueTUBEs for long-term storage at -80° C, or vapor phase liquid nitrogen. Alternatively, the cryofractured tissue can be transferred into cryovials for long-term storage.

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Technology

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