LE220Rsc Focused-ultrasonicator

  • Treatment Power: 0.1–250 W Avg. Incident Power
  • NGS Sample Volumes: 5 to 320 µl

As the highest power and fastest sample processing system in the Covaris portfolio, the LE220Rsc rapidly delivers AFA-energetics® to standard SBS format plates using the scanning mode. It offers tunable acoustic energy, integration with robotic platforms, and more power than the LE220-plus and R230 Focused-ultrasonicators. This instrument enables a variety of novel high power, fast process applications such as lysis of difficult to lyse microorganisms (for example, yeast) in the 96 AFA-TUBE TPX plate and dissolution of difficult to solubilize compounds.

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Technical SpecificationDescription
Primary ApplicationsCell lysis: mammalian, bacterial, yeast, DNA/RNA/Chromatin Shearing, DNA, RNA, Protein, and Biomarker extraction, DNA/ RNA Shearing for NGS, Cell Lysis, High Molecular Weight DNA Extraction
Treatment Power0.1–250 W Avg. Incident Power
Part Number500652
Dimensions61 cm (width), 90 cm (depth), and 48 cm (height)
Power Requirements100 to 240 VAC 500VA, 50 to 60 Hz
Operating EnvironmentAmbient temperature: 19 to 25 °C (66 to 77 °F) Relative humidity: 30 to 70%
Operating Temperature5 to 40 °C
SafetyComplies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory LabelingCE, ETL Mark (for Product Safety), WEEE
SonoLab VersionSonoLab 8
Operating SystemWindows 10
NGS Sample Volumes5 to 320 µl
Recommended Batch SizeUp to 384 Samples
Covaris ConsumablesminiTUBES , milliTUBES , microTUBES , 96 AFA-TUBE TPX plate(with RFID) , 384 AFA-TUBE TPX plate (with RFID)
Upgrade PotentialNo

Quick Guide:

Quick Guide: DNA Shearing with LE220-plus/LE220R-plus/LE220Rsc


Scalable FFPE Sample Preparation Method for Clinical Proteomics LC-MS Assays


E220 & LE220 (-plus, R-plus, Rsc) Setup & Instruction Manual

Product Inserts and User Manuals

Covaris-certified Consumable Guide


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A novel fully automatable approach to improve trypsin digestion of protein samples is presented.

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