ME220 Focused-ultrasonicator

  • Treatment Power: 20 W Avg. Incident Power
  • Sample Processing Capacity: Single Tube
  • NGS Sample Volumes: 15 to 130 µl

The ME220 Focused-ultrasonicator is the multi-sample, multi-application benchtop sample preparation solution for every lab. Capable of 1 to 8 sample batch processing at the bench-top, this compact, easy-to-use system enables precise and accurate results with AFA-energetics®.

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Technical SpecificationDescription
Primary ApplicationsCell lysis: mammalian, bacterial, yeast, cfDNA Extraction from Plasma, DNA Extraction from Dried Blood Spots, DNA/RNA/Chromatin Shearing, DNA/RNA/Total NA/Protein Extraction from FFPE, Tissue lysis and extraction
Treatment Power20 W Avg. Incident Power
Part Number500506
Power Requirements100-240 VAC 500 VA, 50-60Hz, 5 Amp Slo-Blow Fuse
Operating EnvironmentAmbient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30% to 70%
Operating TemperatureProgrammable +6.0 °C to +40.0 °C
SafetyComplies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory LabelingCE, ETL Mark (for Product Safety), WEEE
SonoLab VersionSonoLab 8
Operating SystemWindows 10
ChillerStand-alone benchtop
Sample Processing CapacitySingle Tube
NGS Sample Volumes15 to 130 µl
Recommended Batch Size1 to 8 Samples
Covaris ConsumablesmicroTUBE 8 strip, milliTUBE, miniTUBE (rack required)
Upgrade PotentialYes
Associated AccessoriesME220 Accessories

Key Features

  • Isothermal process
  • Small, compact footprint
  • Non-contact, closed vessel
  • Flexible sample processing volume
  • Highly reproducible results
  • Automatable
  • Sample tracking with 2D barcoded consumables
  • Operates at 500 kHz (Ultrasonic Range)
  • Calibrated to NIST traceable standards


  • No heat-induced bias, high sample recovery
  • Fits on any bench top
  • No cross-contamination, aerosols, or clean-up
  • 15 μl to 1 ml
  • Minimal post-process QC required
  • Sample vessels compatible with liquid handling robots
  • Traceable sample identification
  • Beyond audible range – no discomfort to operators
  • Optimized protocols available and transferable

Quick Guide:

Quick Guide: DNA Shearing with ME220 Focused-ultrasonicator


ME220 User Manual

Product Inserts and User Manuals

Replacing the ME220 Quick Disconnect Insert

Product Inserts and User Manuals

Replacing the ME220 Quick Disconnect Cap

Product Inserts and User Manuals

Replacing the ME220 Particle Filter Element and Gasket

Product Inserts and User Manuals

Covaris-certified Consumable Guide


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