Low-throughput Focused-ultrasonicators

Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples. The M220 and the S220 are the low-throughput Focused-ultrasonicator instruments powered by AFA^®️ technology. Both models offer single tube sample processing capacity in compact, benchtop formats for a variety of applications including DNA/ RNA/ Chromatin Shearing, tissue lysis and extraction, biomolecule extraction from FFPE tissue samples and more.

M220 Focused-ultrasonicator

Compact and easy-to-use system designed for Next-Gen Sequencing applications for fragment sizes between 150 bp and 5 kb.

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S220 Focused-ultrasonicator

A workstation-based instrument capable of extremely rapid and complete homogenization, tissue disruption, and sample extraction

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BROWSE ALL LOW-THROUGHPUT PRODUCTS

“The M220 is a fantastic machine for making ChIP-seq libraries.”

Dr. Rui Yi

Ph.D., The University of Colorado

LOW-THROUGHPUT

MID-THROUGHPUT

HIGH-THROUGHPUT

Focused-ultrasonicator Comparison Guide

M220

S220

Sample Processing Capacity

Single tube

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Single tube

AFA-energetics® Delivery Modes

Indexing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Pulsing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Scanning

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Indexing
Pulsing
Scanning

NGS Sample Volume (dependent on protocol)

15 to 130 ul

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

15 to 130 ul

Compatible Consumable

microTUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

milliTUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

miniTUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

AFA-TUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Flow cells

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

microTUBE
milliTUBE
miniTUBE
AFA-TUBE
Flow cells

Operating Software

SonoLab Software 7

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

SonoLab Software 7

Primary Applications

Nucleic Acid Shearing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

FFPE Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

cfDNA Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

HMW DNA Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Cell Lysis

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Tissue Lysis and Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Bead Mixing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Nucleic Acid Shearing
FFPE Extraction
cfDNA Extraction
High MW DNA Extraction
Cell Lysis
Tissue Lysis and Extraction
Bead Mixing

Instrument Footprint

Width, depth, height

M220 Focused-ultrasonicator

33 cm (w)
38 cm (d)
27 cm (h)

E220 Focused-ultrasonicator

20 cm (w)
53 cm (d)
33 cm (h)

Width, depth, height

33 cm (w)
38 cm (d)
27 cm (h)

20 cm (w)
53 cm (d)
33 cm (h)

Additional Equipment

None

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Chiller required

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

None

Chiller required

Learn More

Focused-ultrasonicator Comparison Guide

ME220

E220

E220 evolution

ML230