Low-throughput Focused-ultrasonicators

Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples. The M220 and the S220 are the low-throughput Focused-ultrasonicator instruments powered by AFA® technology. Both models offer single tube sample processing capacity in compact, benchtop formats for a variety of applications including DNA/ RNA/ Chromatin Shearing, tissue lysis and extraction, biomolecule extraction from FFPE tissue samples and more.

M220 Focused-ultrasonicator

Compact and easy-to-use system designed for Next-Gen Sequencing applications for fragment sizes between 150 bp and 5 kb.

S220 Focused-ultrasonicator

A workstation-based instrument capable of extremely rapid and complete homogenization, tissue disruption, and sample extraction

“The M220 is a fantastic machine for making ChIP-seq libraries.”
Dr. Rui Yi

Ph.D., The University of Colorado

LOW-THROUGHPUT

MID-THROUGHPUT

HIGH-THROUGHPUT

Focused-ultrasonicator Comparison Guide

Single tube

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Single tube

Indexing

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Pulsing

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Scanning

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Indexing
Pulsing
Scanning

15 to 130 ul

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
15 to 130 ul

microTUBE

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

milliTUBE

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

miniTUBE

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

AFA-TUBE

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Flow cells

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
microTUBE
milliTUBE
miniTUBE
AFA-TUBE
Flow cells

SonoLab Software 7

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
SonoLab Software 7

Nucleic Acid Shearing

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

FFPE Extraction

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

cfDNA extraction

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

HMW DNA extraction

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Cell lysis

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Tissue lysis and extraction

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Bead beating

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Nucleic Acid Shearing
FFPE Extraction
cfDNA extraction
High MW DNA extraction
Cell lysis
Tissue lysis and extraction
Bead beating

Width, depth, height

M220 Focused-ultrasonicator
33 cm (w)
38 cm (d)
27 cm (h)
E220 Focused-ultrasonicator
20 cm (w)
53 cm (d)
33 cm (h)
Width, depth, height33 cm (w)
38 cm (d)
27 cm (h)
20 cm (w)
53 cm (d)
33 cm (h)

None

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator

Chiller required

M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
NoneChiller required

Focused-ultrasonicator Comparison Guide

Single tube

ME220
E220
E220 evolution
ML230

8 tubes

ME220
E220
E220 evolution
ML230

96 tubes

ME220
E220
E220 evolution
ML230
Single tube
8 tubes
96 tubes

Indexing

ME220
E220
E220 evolution
ML230

Pulsing

ME220
E220
E220 evolution
ML230

Scanning

ME220
E220
E220 evolution
ML230
Indexing
Pulsing
Scanning

15 - 130 ul

ME220
E220
E220 evolution
ML230

5 - 500 ul

ME220
E220
E220 evolution
ML230
15 to 130 ul
5 to 500 ul

microTUBE

ME220
E220
E220 evolution
ML230

milliTUBE

ME220
E220
E220 evolution
ML230

miniTUBE

ME220
E220
E220 evolution
ML230

AFA-TUBE

ME220
E220
E220 evolution
ML230

Flow cells

ME220
E220
E220 evolution
ML230
microTUBE
milliTUBE
miniTUBE
AFA-TUBE
Flow Cells

SonoLab 7

ME220
E220
E220 evolution
ML230

SonoLab 8

ME220
E220
E220 evolution
ML230

SonoLab 10

ME220
E220
E220 evolution
ML230
SonoLab 7
SonoLab 8
SonoLab 10

Nucleic Acid Shearing

ME220
E220
E220 evolution
ML230

FFPE Extraction

ME220
E220
E220 evolution
ML230

cfDNA extraction

ME220
E220
E220 evolution
ML230

HMW DNA extraction

ME220
E220
E220 evolution
ML230

Cell lysis

ME220
E220
E220 evolution
ML230

Tissue lysis and extraction

ME220
E220
E220 evolution
ML230

Bead beating

ME220
E220
E220 evolution
ML230
Nucleic Acid Shearing
FFPE Extraction
cfDNA extraction
High MW DNA extraction
Cell lysis
Tissue lysis and extraction
Bead beating

Width, depth, height

ME220
47 cm (w)
47 cm (d)
37 cm (h)
E220
61 cm (w)
76 cm (d)
48 cm (h)
E220 evolution
61 cm (w)
76 cm (d)
48 cm (h)
ML230
46.5 cm (w)
51.5 cm (d)
58.5 cm (h)
Width, depth, height47 cm (w)
47 cm (d)
37 cm (h)
61 cm (w)
76 cm (d)
48 cm (h)
61 cm (w)
76 cm (d)
48 cm (h)
46.5 cm (w)
51.5 cm (d)
58.5 cm (h)

Yes

ME220
E220
E220 evolution
ML230

No

ME220
E220
E220 evolution
ML230
Yes
No

Yes

ME220
E220
E220 evolution
ML230

No

ME220
E220
E220 evolution
ML230
Yes
No

Yes

ME220
E220
E220 evolution
ML230

No

ME220
E220
E220 evolution
ML230
Yes
No

None

M220
E220
E220 evolution
ML230

Chiller and WCS 2.0 required

M220
E220
E220 evolution
ML230
NoneChiller and WCS 2.0 requiredNANone

Focused-ultrasonicator Comparison Guide

Single tube

LE220R-plus
LE220-plus
R230
LE220Rsc

8 tubes

LE220R-plus
LE220-plus
R230
LE220Rsc

96 tubes

LE220R-plus
LE220-plus
R230
LE220Rsc

384 well plate

LE220R-plus
LE220-plus
R230
LE220Rsc

1536 well plate

LE220R-plus
LE220-plus
R230
LE220Rsc
Single tube
8 tubes
96 tubes
384 well plate
1536 well plate

Indexing

LE220R-plus
LE220-plus
R230
LE220Rsc

Pulsing

LE220R-plus
LE220-plus
R230
LE220Rsc

Scanning

LE220R-plus
LE220-plus
R230
LE220Rsc
Indexing
Pulsing
Scanning

5 to 320 μl

LE220R-plus
LE220-plus
R230
LE220Rsc

5 to 200 μl

LE220R-plus
LE220-plus
R230
LE220Rsc
5 to 320 μl
5 to 200 μl

microTUBE

LE220R-plus
LE220-plus
R230
LE220Rsc

milliTUBE

LE220R-plus
LE220-plus
R230
LE220Rsc

miniTUBE

LE220R-plus
LE220-plus
R230

AFA-TUBE

LE220R-plus
LE220-plus
R230
LE220Rsc

Flow cells

LE220R-plus
LE220-plus
R230
LE220Rsc
microTUBE
milliTUBE
miniTUBE
AFA-TUBE
Flow cells

SonoLab 8

LE220R-plus
LE220-plus
R230
LE220Rsc

SonoLab 10

LE220R-plus
LE220-plus
R230
LE220Rsc
SonoLab 8
SonoLab 10

Nucleic Acid Shearing

LE220R-plus
LE220-plus
R230
LE220Rsc

FFPE Extraction

LE220R-plus
LE220-plus
R230
LE220Rsc

High MW DNA extraction

LE220R-plus
LE220-plus
R230
LE220Rsc

Cell lysis

LE220R-plus
LE220-plus
R230
LE220Rsc

Tissue lysis and extraction

LE220R-plus
LE220-plus
R230
LE220Rsc

Bead Mixing

LE220R-plus
LE220-plus
R230
LE220Rsc
Nucleic Acid Shearing
FFPE Extraction
HMW DNA extraction
Cell lysis
Tissue lysis and extraction
Bead Mixing

Width, depth, height

LE220R-plus
61 cm (w)
81 cm (d)
48 cm (h)
LE220-plus
61 cm (w)
89 cm (d)
48 cm (h)
R230
36 cm (w)
29 cm (d)
15 cm (h)
LE220Rsc
61 cm (w)
89 cm (d)
48 cm (h)
Width, depth, height61 cm (w)
81 cm (d)
48 cm (h)
61 cm (w)
89 cm (d)
48 cm (h)
36 cm (w)
29 cm (d)
15 cm (h)
61 cm (w)
89 cm (d)
48 cm (h)

Yes

LE220R-plus
LE220-plus
R230
LE220Rsc

No

LE220R-plus
LE220-plus
R230
LE220Rsc
Yes

Yes

LE220R-plus
LE220-plus
R230
LE220Rsc
Yes

Yes

LE220R-plus
LE220-plus
R230
LE220Rsc
Yes

Includes chiller and WCS 2.0

LE220R-plus
LE220-plus
R230
LE220Rsc

Includes electronics module and WCS 3.0

LE220R-plus
LE220-plus
R230
LE220Rsc
Includes chiller and WCS 2.0Includes chiller and WCS 2.0Includes electronics module and WCS 3.0Includes chiller and WCS 2.0