On-Deck Automation Focused-ultrasonicators

Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples. The R-series of Focused-ultrasonicators are high-throughput instruments designed for on-deck integration with liquid handlers. The R230 is the first on-deck, automation enabled Focused-ultrasonicator ready to revolutionize sample preparation on liquid handlers.

R230 Focused-ultrasonicator

Unique, high-throughput Focused-ultrasonicator with multiple energy delivery modes, designed to integrate on-deck in a liquid handler.

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“We are very impressed with our Covaris AFA systems. They are professionally designed, easy to use and highly controllable equipment and our LE220-plus is now one of the most essential and highly used systems in our facility.”

Dr. David Knight

Biological Mass Spectrometry Facility Manager, The University of Manchester

LOW-THROUGHPUT

MID-THROUGHPUT

HIGH-THROUGHPUT

Focused-ultrasonicator Comparison Guide

M220

S220

Sample Processing Capacity

Single tube

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Single tube

AFA-energetics® Delivery Modes

Indexing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Pulsing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Scanning

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Indexing
Pulsing
Scanning

NGS Sample Volume (dependent on protocol)

15 to 130 ul

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

15 to 130 ul

Compatible Consumable

microTUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

milliTUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

miniTUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

AFA-TUBE

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Flow cells

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

microTUBE
milliTUBE
miniTUBE
AFA-TUBE
Flow cells

Operating Software

SonoLab Software 7

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

SonoLab Software 7

Primary Applications

Nucleic Acid Shearing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

FFPE Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

cfDNA Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

High MW DNA Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Cell Lysis

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Tissue Lysis and Extraction

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Bead Mixing

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Nucleic Acid Shearing
FFPE Extraction
cfDNA Extraction
High MW DNA Extraction
Cell Lysis
Tissue Lysis and Extraction
Bead Mixing

Instrument Footprint

Width, depth, height

M220 Focused-ultrasonicator

33 cm (w)
38 cm (d)
27 cm (h)

E220 Focused-ultrasonicator

20 cm (w)
53 cm (d)
33 cm (h)

Width, depth, height

33 cm (w)
38 cm (d)
27 cm (h)

20 cm (w)
53 cm (d)
33 cm (h)

Additional Equipment

None

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

Chiller required

M220 Focused-ultrasonicator

E220 Focused-ultrasonicator

None

Chiller required

Learn More

Focused-ultrasonicator Comparison Guide

ME220

E220

E220 evolution

ML230