Instruments
High-throughput Focused-ultrasonicators
Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples. The LE220-plus, the LE220R-plus, and the LE220Rsc Focused-ultrasonicators are the high-throughput instruments powered by AFA® technology. These instruments are designed for integration with high-throughput laboratory automation with remote set-up and scheduling capability as well as automated waterworks to optimize user-to-user reproducibility. Covaris high-throughput Focused-ultrasonicators have a sample processing capacity of 1 to 96 samples per batch.
LE220-plus
Focused-ultrasonicator
LE220-plus Focused-ultrasonicator
Scalable, automated high-performance sample preparation instrument with processing capacity of 1 to 96 samples.
LE220R-plus Focused-ultrasonicator
Robotic version of the LE220-plus with a light curtain and an opening for a robotic arm.
LE220Rsc Focused-ultrasonicator
The highest powered and fastest sample processing system in the Covaris portfolio.
![](https://d24ci5y4j5ezt1.cloudfront.net/wp/wp-content/uploads/2020/02/quote.png")
“We are very impressed with our Covaris AFA systems. They are professionally designed, easy to use and highly controllable equipment and our LE220-plus is now one of the most essential and highly used systems in our facility.”
Dr. David Knight
Biological Mass Spectrometry Facility Manager, The University of Manchester
LOW-THROUGHPUT
MID-THROUGHPUT
HIGH-THROUGHPUT
Focused-ultrasonicator Comparison Guide
Single tube
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Single tube | | |
Indexing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Pulsing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Scanning
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Indexing | | |
| Pulsing | | |
| Scanning | | |
15 to 130 ul
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| 15 to 130 ul | | |
microTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
milliTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
miniTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
AFA-TUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Flow cells
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| microTUBE | | |
| milliTUBE | | |
| miniTUBE | | |
| AFA-TUBE | | |
| Flow cells | | |
SonoLab Software 7
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| SonoLab Software 7 | | |
Nucleic Acid Shearing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
FFPE Extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
cfDNA Extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
High MW DNA Extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Cell Lysis
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Tissue Lysis and Extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Bead Mixing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Nucleic Acid Shearing | | |
| FFPE Extraction | | |
| cfDNA Extraction | | |
| High MW DNA Extraction | | |
| Cell Lysis | | |
| Tissue Lysis and Extraction | | |
| Bead Mixing | | |
Width, depth, height
M220 Focused-ultrasonicator
33 cm (w)
38 cm (d)
27 cm (h)
38 cm (d)
27 cm (h)
E220 Focused-ultrasonicator
20 cm (w)
53 cm (d)
33 cm (h)
53 cm (d)
33 cm (h)
| Width, depth, height | 33 cm (w) 38 cm (d) 27 cm (h) | 20 cm (w) 53 cm (d) 33 cm (h) |
None
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Chiller required
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| None | Chiller required |
Focused-ultrasonicator Comparison Guide
Single tube
ME220
E220
E220 evolution
ML230
8 tubes
ME220
E220
E220 evolution
ML230
96 tubes
ME220
E220
E220 evolution
ML230
| Single tube | | | | |
| 8 tubes | | | | |
| 96 tubes | | | | |
Indexing
ME220
E220
E220 evolution
ML230
Pulsing
ME220
E220
E220 evolution
ML230
Scanning
ME220
E220
E220 evolution
ML230
| Indexing | | | | |
| Pulsing | | | | |
| Scanning | | | | |
15 - 130 ul
ME220
E220
E220 evolution
ML230
5 - 50 ul
ME220
E220
E220 evolution
ML230
| 15 to 130 ul | | | | |
| 5 to 50 ul | | | | |
microTUBE
ME220
E220
E220 evolution
ML230
milliTUBE
ME220
E220
E220 evolution
ML230
miniTUBE
ME220
E220
E220evolution
ML230
AFA-TUBE
ME220
E220
E220 evolution
ML230
Flow cells
ME220
E220
E220 evolution
ML230
| microTUBE | | | | |
| milliTUBE | | | | |
| miniTUBE | | | | |
| AFA-TUBE | | | | |
| Flow Cells | | | | |
SonoLab 7
ME220
E220
E220 evolution
ML230
SonoLab 8
ME220
E220
E220 evolution
ML230
SonoLab 10
ME220
E220
E220 evolution
ML230
| SonoLab 7 | | | | |
| SonoLab 8 | | | | |
| SonoLab 10 | | | | |
Nucleic Acid Shearing
ME220
E220
E220 evolution
ML230
FFPE Extraction
ME220
E220
E220 evolution
ML230
cfDNA Extraction
ME220
E220
E220 evolution
ML230
High MW DNA Extraction
ME220
E220
E220 evolution
ML230
Cell Lysis
ME220
E220
E220 evolution
ML230
Tissue Lysis and Extraction
ME220
E220
E220 evolution
ML230
Bead Mixing
ME220
E220
E220 evolution
ML230
| Nucleic Acid Shearing | | | | |
| FFPE Extraction | | | | |
| cfDNA Extraction | | | | |
| High MW DNA Extraction | | | | |
| Cell Lysis | | | | |
| Tissue Lysis and Extraction | | | | |
| Bead Mixing | | | | |
Width, depth, height
ME220
47 cm (w)
47 cm (d)
37 cm (h)
47 cm (d)
37 cm (h)
E220
61 cm (w)
76 cm (d)
48 cm (h)
76 cm (d)
48 cm (h)
E220 evolution
61 cm (w)
76 cm (d)
48 cm (h)
76 cm (d)
48 cm (h)
ML230
46.5 cm (w)
51.5 cm (d)
58.5 cm (h)
51.5 cm (d)
58.5 cm (h)
| Width, depth, height | 47 cm (w) 47 cm (d) 37 cm (h) | 61 cm (w) 76 cm (d) 48 cm (h) | 61 cm (w) 76 cm (d) 48 cm (h) | 46.5 cm (w) 51.5 cm (d) 58.5 cm (h) |
Yes
ME220
E220
E220 evolution
ML230
No
ME220
E220
E220 evolution
ML230
| Yes | | | | |
| No | | | | |
Yes
ME220
E220
E220 evolution
ML230
No
ME220
E220
E220 evolution
ML230
| Yes | | | | |
| No | | | | |
Yes
ME220
E220
E220 evolution
ML230
No
ME220
E220
E220 evolution
ML230
| Yes | | | | |
| No | | | | |
None
M220
E220
E220 evolution
ML230
Chiller and WCS 2.0 required
M220
E220
E220 evolution
ML230
| None | Chiller and WCS 2.0 required | NA | None |
Focused-ultrasonicator Comparison Guide
Single tube
LE220R-plus
LE220-plus
R230
LE220Rsc
8 tubes
LE220R-plus
LE220-plus
R230
LE220Rsc
96 tubes
LE220R-plus
LE220-plus
R230
LE220Rsc
384 well plate
LE220R-plus
LE220-plus
R230
LE220Rsc
1536 well plate
LE220R-plus
LE220-plus
R230
LE220Rsc
| Single tube | | | | |
| 8 tubes | | | | |
| 96 tubes | | | | |
| 384 well plate | | | | |
| 1536 well plate | | | | |
Indexing
LE220R-plus
LE220-plus
R230
LE220Rsc
Pulsing
LE220R-plus
LE220-plus
R230
LE220Rsc
Scanning
LE220R-plus
LE220-plus
R230
LE220Rsc
| Indexing | | | | |
| Pulsing | | | | |
| Scanning | | | | |
5 to 320 μl
LE220R-plus
LE220-plus
R230
LE220Rsc
5 to 200 μl
LE220R-plus
LE220-plus
R230
LE220Rsc
| 5 to 320 μl | | | | |
| 5 to 200 μl | | | | |
microTUBE
LE220R-plus
LE220-plus
R230
LE220Rsc
milliTUBE
LE220R-plus
LE220-plus
R230
LE220Rsc
miniTUBE
LE220R-plus
LE220-plus
R230
AFA-TUBE
LE220R-plus
LE220-plus
R230
LE220Rsc
Flow cells
LE220R-plus
LE220-plus
R230
LE220Rsc
| microTUBE | | | | |
| milliTUBE | | | | |
| miniTUBE | | | | |
| AFA-TUBE | | | | |
| Flow cells | | | | |
SonoLab 8
LE220R-plus
LE220-plus
R230
LE220Rsc
SonoLab 10
LE220R-plus
LE220-plus
R230
LE220Rsc
| SonoLab 8 | | | | |
| SonoLab 10 | | | | |
Nucleic Acid Shearing
LE220R-plus
LE220-plus
R230
LE220Rsc
FFPE Extraction
LE220R-plus
LE220-plus
R230
LE220Rsc
High MW DNA Extraction
LE220R-plus
LE220-plus
R230
LE220Rsc
Cell Lysis
LE220R-plus
LE220-plus
R230
LE220Rsc
Tissue Lysis and Extraction
LE220R-plus
LE220-plus
R230
LE220Rsc
Bead Mixing
LE220R-plus
LE220-plus
R230
LE220Rsc
| Nucleic Acid Shearing | | | | |
| FFPE Extraction | | | | |
| HMW DNA Extraction | | | | |
| Cell Lysis | | | | |
| Tissue Lysis and Extraction | | | | |
| Bead Mixing | | | | |
Width, depth, height
LE220R-plus
61 cm (w)
81 cm (d)
48 cm (h)
81 cm (d)
48 cm (h)
LE220-plus
61 cm (w)
89 cm (d)
48 cm (h)
89 cm (d)
48 cm (h)
R230
36 cm (w)
29 cm (d)
15 cm (h)
29 cm (d)
15 cm (h)
LE220Rsc
61 cm (w)
89 cm (d)
48 cm (h)
89 cm (d)
48 cm (h)
| Width, depth, height | 61 cm (w) 81 cm (d) 48 cm (h) | 61 cm (w) 89 cm (d) 48 cm (h) | 36 cm (w) 29 cm (d) 15 cm (h) | 61 cm (w) 89 cm (d) 48 cm (h) |
Yes
LE220R-plus
LE220-plus
R230
LE220Rsc
No
LE220R-plus
LE220-plus
R230
LE220Rsc
| Yes | | | | |
Yes
LE220R-plus
LE220-plus
R230
LE220Rsc
| Yes | | | | |
Yes
LE220R-plus
LE220-plus
R230
LE220Rsc
| Yes | | | | |
Includes chiller and WCS 2.0
LE220R-plus
LE220-plus
R230
LE220Rsc
Includes electronics module and WCS 3.0
LE220R-plus
LE220-plus
R230
LE220Rsc
| Includes chiller and WCS 2.0 | Includes chiller and WCS 2.0 | Includes electronics module and WCS 3.0 | Includes chiller and WCS 2.0 |