Consumables - Tubes and Vials
AFA® Process Vessels
AFA Process Vessels enable efficient, high power, and low temperature processing of Formulations and Drug Delivery Systems in AFA Focused-ultrasonicators. Unprecedented control and maintenance of low sample temperatures during processing ensures sensitive API maintains maximum bioactivity during the production of liposome, nanoemulsion, or nanoparticle formulations. Sample temperatures are constantly monitored in real time with in-line temperature sensors.
Tube & Cap 16 x 100 mm
Pharmaceutical grade borosilicate, hardened glass.
- Insert materials: Teflon septa, glass (AFA-grade)
- Range of sizes from 1 to 18 mL
AFA Batch Vessels High Power: AFA Stainless Steel
Pharmaceutical grade 316 stainless steel.
- 0.3 and 2.0 mL batch volumes
- First step for scalability studies
AFA Batch Vessels
22 ml: AFA-Liposome formation
2 ml: PLGA AFA-Nanoparticle formation
AFA-Nanoemulsion formation
High heat flux exchanger with Dean vortex cooling design
- Control sample temperatures from 4 to 40° C
- 316 Stainless wetted surfaces
AFA Process Vessel Compatibility Guide
AFA Process Vessel Features and Benefits
| FEATURE | BENEFIT |
| Reproducible product specification | Automated, computer controlled processing |
| 100% Recovery | Formulate with limited material with no waste |
| Non-contact | Eliminates risk of contamination |
| Scalable | 100 µl to continuous process flow with PAT feedback |
| “Temperature-tunable” process | “Temperature-tunable” process |
Unique Constructs and Intravenous Preparations
Fig 1: 12 ml of ibuprofen before and after 5 minutes
Unique Constructs and Intravenous Preparations
Fig 2: Size distribution by volume
Fig 3: Size distribution by time
Fig 4: AFA Flow Vessels: Continuous Flow Scale