S220 Focused-ultrasonicator

SKU
500217
  • Treatment Power: 100 W Avg. Incident Power
  • Sample Processing Capacity: Single tube processing
  • NGS Sample Volumes: 15 to 130 µl

The S220 Focused-ultrasonicator is a versatile, high power system engineered for pre-analytical sample processing using Covaris’ patented Adaptive Focused Acoustics® (AFA®). Utilizing a spherical acoustic transducer, specifically designed acoustical cuvettes and advanced electronics, AFA delivers controlled energy precisely and accurately to sample volumes from 15 μl to 18 ml.

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Technical Specification Description
Primary Applications Cell lysis: mammalian, bacterial, yeast, cfDNA Extraction from Plasma, DNA Extraction from Dried Blood Spots, DNA/RNA/Chromatin Shearing, DNA/RNA/Total NA/Protein Extraction from FFPE, Tissue lysis and extraction
Treatment Power 100 W Avg. Incident Power
Part Number 500217
Power Requirements 100-240 VAC 500 VA, 50-60 Hz
Operating Environment Ambient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30% to 70%
Operating Temperature 19 °C to 25 °C (66 °F to 77 °F)
Safety Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements"
Regulatory Labeling CE, ETL Mark (for Product Safety), WEEE
SonoLab Version SonoLab 7
Operating System Microsoft Windows XP SP3 minimum or Windows 7
WCS Yes
Chiller Chiller Required-Not included, sold separately
Sample Processing Capacity Single tube processing
NGS Sample Volumes 15 to 130 µl
Recommended Batch Size NA
Covaris Consumables microTUBE, milliTUBE, miniTUBE, Large volume consumables, Flow cells
Upgrade Potential No
Associated Accessories S220 Accessories

Key Features

  • Continuous Temperature Control
  • Non-contact, closed vessel
  • Accurate, Precise, and Controlled acoustic energy
  • Accommodates a broad sample volume range
  • Ultrasonic

Benefits

  • No heat damage, higher recovery
  • No cross contamination, no aerosols, no clean up
  • Processes and protocols are highly reproducible
  • Multiple applications are accommodated in a single instrument
  • AFA does not require sound-proofing or special precautions

Quick Guide:

DNA miniTUBE – Blue for 220 Series

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Quick Guide:

DNA miniTUBE – Clear for 220 Series

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Quick Guide:

DNA miniTUBE – Red for 220 Series

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Quick Guide:

DNA Shearing Quick Guide: microTUBE-15 with S220/E220 Focused-ultrasonicator.

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Quick Guide:

DNA Shearing with microTUBEs (<1.5kb fragments) S220/E220

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Quick Guide:

Quick Guide: DNA Shearing with S220 Focused-ultrasonicator

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Quick Guide:

RNA Shearing with S, E, and LE-Series Focused-ultrasonicators

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S220 User Manual

Product Inserts and User Manuals
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S-Series Flow Vessels Adapter Kit (500392)

Product Inserts and User Manuals
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The Yin-Yang of Sample Preparation: Reagent optimization for maximal yield, activity, and preservation of biomarkers using Adaptive Focused Acoustics®(AFA®)

Posters
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Robust pre-analytical sample preparation process preserves the accuracy and fidelity of protein phosphorylation states

Posters
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Universal Sample Processing Of Multiple Sample Types For Reproducible Proteomic Sample Preparation

Posters
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S220/S220x/S220R Focused-ultrasonicator

Brochures
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Formulation and Drug Delivery Breakthrough processing for poorly soluble API’s

Brochures
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Active Extraction of Native Proteins from Yeast using Covaris Adaptive Focused Acoustics® (AFA®)

Native protein extraction reagents were tested for total protein yield and preservation of enzymatic activity using a “passive extraction” or an AFA-based “active extraction” method,...

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Active paraffin removal from FFPE tissues with Adaptive Focused Acoustics

Covaris developed a method of active paraffin removal from FFPE tissues using AFA technology. AFA treatment is applied to a FFPE sample and paraffin is...

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AFA-based Sputum Liquification to Enable Downstream Microbial Analysis

Sputim Liquification

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DNA Extraction from FFPE samples with Covaris Focused-ultrasonicators

When an Adaptive Focused Acoustics (AFA) treatment is applied to a FFPE sample to extract DNA, it simultaneously deparaffinizes the sample, emulsifies the paraffin, and...

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Microbiome Sample Preparation: Efficient DNA Extraction and Optional Mechanical Shearing

DNA Extraction

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Preparation of whole body Caenorhabditis elegans extracts for chromatin immunoprecipitation using the Covaris® S220 Focused-ultrasonicator

This application note provides a sample preparation protocol using the Covaris S220 that can be used by investigators looking to process whole body C. elegans...

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