Quick Guide: DNA Shearing with ML230 Focused-ultrasonicator
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ML230 Focused-ultrasonicator
SKU
500656
- Treatment Power: .5–110 W Avg. Incident Power/1.5–450 W PIP
- Sample Processing Capacity: 1-8 Samples
- NGS Sample Volumes: 5 to 50 µl
The Parallel Sample Processing Platform Powered by Covaris Adaptive Focused Acoustics® (AFA®). The ML230 Focused-ultrasonicator enables parallel processing of up to 8 samples simultaneously and is compatible with the AFA-TUBE conical style strip tubes with no thread or septa. The instrument has a small footprint, saving bench space, with a built-in touchscreen that is easy to clean and maintain. The instrument also has USB ports that allow users to export/import methods, rack definitions, history files etc.
| Technical Specification | Description |
|---|---|
| Primary Applications | DNA, RNA, Protein, and Biomarker extraction, DNA/ RNA Shearing for NGS |
| Treatment Power | .5–110 W Avg. Incident Power/1.5–450 W PIP |
| Part Number | 500656 |
| Power Requirements | 100 to 240 VAC 500VA, 50 to 60 Hz |
| Operating Environment | 15 °C to 25 °C |
| Operating Temperature | 10 °C to 40 °C |
| Safety | Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements |
| Regulatory Labeling | CE, ETL Mark (for Product Safety), WEEE |
| SonoLab Version | SonoLab 10 |
| Operating System | Windows 10 |
| WCS | Integrated |
| Chiller | Integrated |
| Sample Processing Capacity | 1-8 Samples |
| NGS Sample Volumes | 5 to 50 µl |
| Recommended Batch Size | 1 to 8 Samples |
| Covaris Consumables | 8 microTUBE-50 AFA Fiber H Slit Strip V2, 8 microTUBE-130 AFA Fiber H Slit Strip V2, 8 microTUBE-130 AFA Fiber Strip V2, 8 AFA-TUBE TPX Strip, 8 microtube-50 AFA Fiber Strip V2 |
| Upgrade Potential | No |
| Associated Accessories | ML230 Accessories |
Key Features
- AFA-energetics® (active, non-contact, isothermal acoustic energy)
- Intuitive touchscreen control
- Automated water management
- Simultaneous processing
- Embedded RFID Reader
Benefits
- Precise and accurate results with the robust AFA process for many applications
- Easy-to-use software user interface that is easy to clean
- Easy to maintain with reduced user variability
- Preserves labile biomolecules
- Guarantees proper consumable matches the correct method and tracks lot information
Clinical Tumor Tissue Evaluated with Illumina® TruSight™ Oncology 500 (NGS) Assay and Sheared on the Covaris ML230 Focused-ultrasonicator
Abstract: DNA fragmentation is a critical step in the preparation of high-quality next generation sequencing (NGS) libraries. Covaris Adaptive Focused Acoustics® (AFA®) technology guarantees highly...
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