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Watch On-Demand: Optimized DNA Fragmentation for Simultaneous Genome & Methylome Sequencing using the Illumina 5-base Solution
Covaris Adaptive Focused Acoustics® (AFA®) technology enables precise, reproducible DNA fragmentation, supporting consistent coverage, high mapping rates, and unbiased CpG representation across sample types and input levels. This enables high-confidence variant calling and accurate methylation profiling in workflows leveraging the Illumina 5-base genome solution. For challenging sample types such as FFPE, Covaris truXTRAC® workflows enable the extraction of high-quality DNA, providing a reliable foundation for downstream fragmentation and multiomic sequencing.
Watch the video to learn about Covaris validated performance with Illumina 5-base workflows:
• Consistent coverage and mapping performance across instruments and input amounts
• High concordance in methylation detection across conditions
• Unbiased GC and CpG coverage for accurate multiomic profiling
• High sensitivity and precision in variant detection
• Robust performance across sample types, including FFPE and tumor samples
• Reliable DNA recovery from FFPE samples using truXTRAC® extraction workflows