Instruments
Low-throughput Focused-ultrasonicators
Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly-controlled and focused acoustic energy to your samples. The M220 and the S220 are the low-throughput Focused-ultrasonicator instruments powered by AFA® technology. Both models offer single tube sample processing capacity in compact, benchtop formats for a variety of applications including DNA/ RNA/ Chromatin Shearing, tissue lysis and extraction, biomolecule extraction from FFPE tissue samples and more.
M220 Focused-ultrasonicator
Compact and easy-to-use system designed for Next-Gen Sequencing applications for fragment sizes between 150 bp and 5 kb.
S220 Focused-ultrasonicator
A workstation-based instrument capable of extremely rapid and complete homogenization, tissue disruption, and sample extraction
![](/wp/wp-content/uploads/2020/02/quote.png")
“The M220 is a fantastic machine for making ChIP-seq libraries.”
Dr. Rui Yi
Ph.D., The University of Colorado
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Focused-ultrasonicator Comparison Guide Low throughput
Single tube
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Single tube | | |
Indexing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Pulsing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Scanning
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Indexing | | |
| Pulsing | | |
| Scanning | | |
15 to 130 ul
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| 15 to 130 ul | | |
microTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
milliTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
miniTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
AFA-TUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Flow cells
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| microTUBE | | |
| milliTUBE | | |
| miniTUBE | | |
| AFA-TUBE | | |
| Flow cells | | |
SonoLab Software 7
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| SonoLab Software 7 | | |
Nucleic Acid Shearing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
FFPE Extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
cfDNA extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
High MW DNA extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Cell lysis
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Tissue lysis and extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Bead beating
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Nucleic Acid Shearing | | |
| FFPE Extraction | | |
| cfDNA extraction | | |
| High MW DNA extraction | | |
| Cell lysis | | |
| Tissue lysis and extraction | | |
| Bead beating | | |
Width, depth, height
M220 Focused-ultrasonicator
33 cm (w)
38 cm (d)
27 cm (h)
38 cm (d)
27 cm (h)
E220 Focused-ultrasonicator
20 cm (w)
53 cm (d)
33 cm (h)
53 cm (d)
33 cm (h)
| Width, depth, height | 33 cm (w) 38 cm (d) 27 cm (h) | 20 cm (w) 53 cm (d) 33 cm (h) |
None
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Chiller required
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| None | Chiller required |
Focused-ultrasonicator Comparison Guide high throughput
Single tube
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Single tube | | |
Indexing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Pulsing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Scanning
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Indexing | | |
| Pulsing | | |
| Scanning | | |
15 to 130 ul
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| 15 to 130 ul | | |
microTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
milliTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
miniTUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
AFA-TUBE
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Flow cells
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| microTUBE | | |
| milliTUBE | | |
| miniTUBE | | |
| AFA-TUBE | | |
| Flow cells | | |
SonoLab Software 7
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| SonoLab Software 7 | | |
Nucleic Acid Shearing
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
FFPE Extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
cfDNA extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
High MW DNA extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Cell lysis
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Tissue lysis and extraction
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Bead beating
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| Nucleic Acid Shearing | | |
| FFPE Extraction | | |
| cfDNA extraction | | |
| High MW DNA extraction | | |
| Cell lysis | | |
| Tissue lysis and extraction | | |
| Bead beating | | |
Width, depth, height
M220 Focused-ultrasonicator
33 cm (w)
38 cm (d)
27 cm (h)
38 cm (d)
27 cm (h)
E220 Focused-ultrasonicator
20 cm (w)
53 cm (d)
33 cm (h)
53 cm (d)
33 cm (h)
| Width, depth, height | 33 cm (w) 38 cm (d) 27 cm (h) | 20 cm (w) 53 cm (d) 33 cm (h) |
None
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
Chiller required
M220 Focused-ultrasonicator
E220 Focused-ultrasonicator
| None | Chiller required |