Whole-genome sequencing is essential for genomics research, but preparing high-quality libraries from low DNA inputs is a growing challenge in applications such as oncology and liquid biopsy. Ultra-low DNA inputs often lead to uneven coverage and reduced variant accuracy. Covaris’ truCOVER® workflow uses Adaptive Focused Acoustics® (AFA®) to simplify library preparation while ensuring consistent results across sample inputs – even those in the sub-nanogram range. In this Science Spotlight episode, Vanessa Process, a scientist at Covaris, shows how truCOVER® library prep supports high-quality WGS for advanced research and clinical applications.