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Affinity-based Enrichment Analyses of DNA Methylation MCIp, MeDIP, hMeDIP
October 19, 2018Pairing Covaris truChIP® and AFA® with the Chromatrap® Bead-free Immunoprecipitation Technology
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Searching for Innovative, Cost-Effective Product Options
October 15, 2018 (Genetic Engineering & Biotechnology News, Vol. 38, No. 18)
Author: Lynne Lederman, Ph.D.
In the past five years, Covaris has moved with NGS into the clinical arena, where the library preparation workflow has been complicated and time-consuming. “We have been working really hard in simplifying the workflow for NGS, using AFA technology to replace some of the pipetting and passive diffusion elution steps of the NGS workflow,” says Hamid Khoja, Ph.D., principal scientist, Covaris. “We are also working on reducing the hybridization time for the enrichment procedure. Typically, that requires 16 to 24 hours. In some of our initial data we have been able to reduce that to less than an hour.