This year’s meeting is an acknowledgement of how far proteomics has travelled. We are now in the era where generating multiple comprehensive proteomes in a day is becoming routine. The field is now utilising the underlying technologies to go well beyond traditional proteome analyses. Proteomic experiments can now capture not only quantitative data or PTM data but also protein interaction, spacial, structural and temporal information. The 2022 meeting will celebrate next generation technologies and how they are transforming applications from scientific research to commercial quality control and civil security.